Drug Interactions With Pioglitazone and Glimepiride

As with all medications, there are potential drug interactions with pioglitazone and glimepiride. When it is taken at the same time as medicines such as beta blockers, diuretics, or nonsteroidal anti-inflammatory drugs, the risk of developing extremely high or low blood sugar levels is increased. Drug interactions with pioglitazone and glimepiride may be dangerous, and your healthcare provider may need to monitor you more closely and adjust your dosage.

 

Drug Interactions With Pioglitazone and Glimepiride: An Overview

Pioglitazone and glimepiride (Duetact®) can potentially interact with several medicines. Some of the medicines that may lead to drug interactions with pioglitazone and glimepiride include:
 
 
 
  • Certain antifungals, including fluconazole (Diflucan®), ketoconazole (Nizoral®), and miconazole
     
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Certain seizure medications, including:
 
 
  • Corticosteroids, such as:
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®).
 
  • Diuretics, such as:
 
 
  • Estrogens
     
  • Gemfibrozil (Lopid®)
     
  • Isoniazid
     
  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Rifampin (Rifadin®) or rifapentine (Priftin®)
     
  • Ritonavir (Norvir®)
     
  • Thyroid medications, such as:
 
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Pioglitazone and Glimepiride Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;