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Drug Interactions With Pioglitazone and Glimepiride

Rifampin or Rifapentine
Taking pioglitazone and glimepiride with rifampin or rifapentine can decrease the level of pioglitazone and glimepiride in your blood, perhaps making it less effective. Your healthcare provider may need to monitor you more closely and/or adjust your dose of these medications, depending on your particular situation.
 
Ritonavir
Taking pioglitazone and glimepiride with ritonavir can increase the level of pioglitazone and glimepiride in your blood, potentially increasing your risk of side effects. To prevent this interaction, your healthcare provider may need to decrease your dose of pioglitazone and glimepiride.
 
Thyroid Medications
If pioglitazone and glimepiride is taken with thyroid medications, this can make pioglitazone and glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and glimepiride dose, especially when starting or stopping a thyroid medication.
 
Warfarin
Taking pioglitazone and glimepiride with warfarin can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and glimepiride dose, especially when starting or stopping warfarin.
 

Drug Interactions With Pioglitazone and Glimepiride: Final Thoughts

It is possible that not all drug interactions with pioglitazone and glimepiride were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
Healthy Eating for People With Diabetes

Pioglitazone and Glimepiride Info

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