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Drug Interactions With Pioglitazone and Glimepiride

Isoniazid
Taking pioglitazone and glimepiride with isoniazid can make pioglitazone and glimepiride less effective, increasing your chances of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and glimepiride dose, especially when starting or stopping isoniazid.
 
Niacin
Taking pioglitazone and glimepiride with niacin can make pioglitazone and glimepiride less effective, possibly increasing your chance of high blood sugar (hyperglycemia). To prevent this interaction, you may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and glimepiride dose, especially when starting or stopping niacin.
 
Nonsteroidal Anti-Inflammatory Drugs
Taking pioglitazone and glimepiride with NSAIDs can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and glimepiride dose, especially when starting or stopping an NSAID.
 
Oral Contraceptives
If pioglitazone and glimepiride is taken with oral contraceptives (birth control pills), this can make pioglitazone and glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and glimepiride dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Combining pioglitazone and glimepiride with phenothiazines can make pioglitazone and glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and glimepiride dose, especially when starting or stopping a phenothiazine.
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Pioglitazone and Glimepiride Info

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