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Drug Interactions With Pioglitazone and Glimepiride

More Detail on Pioglitazone and Glimepiride Interactions

The following sections explain in detail the potentially negative interactions that can occur when pioglitazone and glimepiride are taken with any of the drugs listed above.
 
Atazanavir
Taking pioglitazone and glimepiride with atazanavir can increase the level of pioglitazone and glimepiride in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to adjust your dose of pioglitazone and glimepiride when starting and stopping atazanavir to prevent this interaction.
 
Beta Blockers
Taking pioglitazone and glimepiride with beta blockers can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your Amaryl dose, especially when starting or stopping a beta blocker.
 
Certain Antifungals
If pioglitazone and glimepiride is taken with certain antifungals, this can increase the level of pioglitazone and glimepiride in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and/or adjust your dose of these medications, depending on your particular situation.
 
Certain Decongestants
Combining pioglitazone and glimepiride with certain decongestants can make pioglitazone and glimepiride less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and glimepiride dose, especially when starting or stopping decongestants. Make sure you check with your healthcare provider before taking any over-the-counter cough or cold products, as these medications often contain decongestants.
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Pioglitazone and Glimepiride Info

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