Drug Interactions With NPH Insulin/Regular Insulin
More Information on Interactions With NPH Insulin/Regular Insulin
Any of the medications discussed in this article may increase the risk of low blood sugar when combined with NPH insulin/regular insulin (or any other insulin medications). Therefore, it is a good idea to check with your healthcare provider before you take any of these medications with NPH insulin/regular insulin. Your healthcare provider may recommend that you monitor your blood sugar levels more closely for awhile to see if you need to adjust your NPH insulin/regular insulin dosage. In some cases, an alternative medication that does not cause drug interactions may be recommended. If you do take a medication that interacts with NPH insulin/regular insulin, it is usually best to take it either regularly or not at all, since taking it sporadically can cause blood sugar changes that are difficult to predict.
It is also important to check with your healthcare provider any time you stop taking any of the medications listed in this article or any time your dose of such medication is adjusted. Again, you may need to monitor your blood sugar levels more closely for awhile, and your healthcare provider may need to adjust your dose of NPH insulin/regular insulin.
For the thiazolidinediones (TZDs), there is an additional type of drug interaction that may occur. TZDs can cause fluid retention, possibly causing or worsening serious problems such as heart failure. Insulin may increase these risks.
Many NPH insulin/regular insulin drug interactions were not discussed in this article, including interactions that may cause high blood sugar (hyperglycemia). These interactions are not usually immediately dangerous, although they may become dangerous if they are not treated. In these cases, you may need to have your dose of NPH insulin/regular insulin adjusted. It is a good idea to get into the practice of checking with your healthcare provider any time you start, stop, or change the dose of any medication, including non-prescription medications.