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Precautions and Warnings With Nateglinide

Precautions and warnings with nateglinide to be aware of include potential drug interactions, the risk of side effects, and people who should not take the drug. For example, people who have type 1 diabetes or diabetic ketoacidosis should avoid this medication. Precautions and warnings with nateglinide also extend to people who have severe kidney or liver problems and those with certain allergies.

Nateglinide: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking nateglinide (Starlix®) if you have:
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Will be having surgery.
In addition, tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Nateglinide

Warnings and precautions to be aware of prior to taking nateglinide include the following:
  • Nateglinide can cause low blood sugar (hypoglycemia), which is a potentially dangerous condition. To reduce this risk, the medication should be taken only before meals. If you skip a meal, you should also skip your dose of nateglinide.
Low blood sugar is more common in elderly people and in people with adrenal, pituitary, liver, or kidney problems, as well as during fasting before surgery and after prolonged exercise. Symptoms of low blood sugar include irritability, trembling, cold sweats, and blurry vision, among other things (see Starlix and Blood Sugar).
  • Fever, infections, injury, or surgery can temporarily increase blood sugar, even in people with well-controlled diabetes. Nateglinide may not be enough to treat diabetes at these times, and the use of insulin may be required. Contact your healthcare provider if you have a fever, infection, injury, or will be having surgery. Also, make sure you know the symptoms of high blood sugar and how to check your blood sugar levels.
  • Nateglinide has not been studied in people with moderate or severe liver disease, including liver failure or cirrhosis. If you have liver disease, talk with your healthcare provider before taking the drug.
  • Nateglinide can interact with certain medications (see Drug Interactions With Nateglinide).
  • Nateglinide is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy. Talk to your healthcare provider if you are taking the drug and pregnancy occurs (see Starlix and Pregnancy).
  • It is not known if nateglinide passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider.
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