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Drug Interactions With Nateglinide

Diuretics
If nateglinide is combined with diuretics, this can make nateglinide less effective, potentially increasing your chance of high blood sugar (hyperglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your nateglinide dose, especially when starting or stopping a diuretic.
 
Fluconazole
Taking nateglinide with fluconazole can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your nateglinide dose.
 
Monoamine Oxidase Inhibitors
If nateglinide is taken with monoamine oxidase inhibitors, this can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your nateglinide dose, especially when starting or stopping an MAOI, to prevent this interaction from occurring.
 
Nonsteroidal Anti-Inflammatory Drugs
Taking nateglinide with NSAIDs can increase your risk of low blood sugar (hypoglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your nateglinide dose, especially when stopping or starting an NSAID.
 
Oxandrolone
Taking nateglinide with oxandrolone can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your nateglinide dose.
 
Phenytoin
Taking nateglinide with phenytoin can make nateglinide less effective. You will probably need to monitor your blood sugar more closely and report any significant changes to your healthcare provider when starting or stopping phenytoin.
Common Symptoms of Diabetic Neuropathy

Nateglinide for Diabetes

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