Endocrine System Home > Sitagliptin and Metformin Extended-Release

Healthcare providers may prescribe sitagliptin and metformin extended-release for the treatment of type 2 diabetes. This combination drug works by lowering the amount of sugar produced by the liver and by increasing the amount of insulin produced in response to meals. It comes in tablet form and is taken once daily. Some people may experience side effects, such as diarrhea, headaches, and symptoms of the common cold.

 

What Is Sitagliptin and Metformin Extended-Release?

Sitagliptin and metformin extended-release (Janumet® XR) is a prescription medication used in combination with an appropriate diet and regular exercise to treat adults with type 2 diabetes. It contains two diabetes medicines, as the name implies: sitagliptin (Januvia®) and metformin extended-release (Glucophage XR®, Glutametz®, or Fortamet®).
 
Janumet (sitagliptin and metformin) is similar to sitagliptin and metformin extended-release, but contains immediate-release metformin instead of the extended-release formulation. Because it does not contain an extended-release version of metformin, regular Janumet must be taken twice a day.
 
(Click What Is Sitagliptin and Metformin Extended-Release Used For? for more information on this topic, including possible off-label uses.)
 

Are There Side Effects?

Just like any medicine, sitagliptin and metformin extended-release can cause side effects. However, not everyone who takes the drug will experience problems. Most people tolerate it quite well.
 
If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious reactions are less common.
 
Common side effects seen with sitagliptin and metformin extended-release include but are not limited to:
   
(Click Sitagliptin and Metformin Extended-Release Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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