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Common Side Effects With Rosiglitazone and Metformin

Rosiglitazone and metformin has been studied thoroughly in clinical trials in which side effects of a group of people taking the drug are documented and compared to another group not taking the medicine.
Based on these studies, the most common side effects of rosiglitazone and metformin include:
  • Nausea or vomiting -- in up to 16 percent of people
  • Upper respiratory tract infections (similar to the common cold) -- up to 16 percent
  • Diarrhea -- up to 14 percent
  • Headache -- up to 11 percent
  • Upset stomach or heartburn -- up to 10 percent
  • Dizziness -- up to 8 percent
  • Injury -- up to 8 percent
  • Anemia -- up to 7.1 percent
  • Sinus infection or irritation -- up to 6.2 percent
  • Fluid retention or water weight gain and swelling (edema) -- up to 6 percent (see Avandamet and Weight Gain)
  • Abdominal pain (or stomach pain) -- up to 6 percent.
Other common side effects of this drug (occurring in 1 percent to 6 percent of people) include:


Also, a recent study found that up to 9.3 percent of women taking Avandia® (rosiglitazone) develop broken bones -- especially of the arms, hands, or feet. Since rosiglitazone is one of the components of rosiglitazone and metformin, it is possible that women taking Avandamet may also be at risk for broken bones.


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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