Endocrine System Home > Rosiglitazone and Glimepiride

Who Makes Rosiglitazone and Glimepiride?

Rosiglitazone and glimepiride is manufactured by GlaxoSmithKline.

How Does Rosiglitazone and Glimepiride Work?

Rosiglitazone and glimepiride is a combination of two diabetes medicines. These two medications work differently and have different effects in the body:
  • Rosiglitazone is part of a group of medications called thiazolidinediones (or sometimes called "glitazones"). Rosiglitazone helps to improve insulin sensitivity, meaning that it helps your body to use its natural insulin better. This helps to lower blood sugar and keep it under better control.
  • Glimepiride is part of a class of diabetes medications known as sulfonylureas. As a sulfonylurea, glimepiride helps the pancreas to produce more insulin. Glimepiride may also help the cells of the body respond to insulin better. Because of these effects, blood sugar levels decrease.
Rosiglitazone and glimepiride is not used to treat type 1 diabetes.

Rosiglitazone and Glimepiride Effects

There have been several studies examining the effects of rosiglitazone and glimepiride for the treatment of type 2 diabetes.
Rosiglitazone and Glimepiride and Hemoglobin A1c
Hemoglobin A1c (HbA1c) is a test used to measure long-term blood sugar control. For people without diabetes, HbA1c results are usually less than 6 percent, while people with diabetes usually have higher results. In one study, people taking rosiglitazone and glimepiride lowered their HbA1c by up to 2.5 percent on average, while people taking just rosiglitazone or just glimepiride lowered their HbA1c by only 1.7 to 1.8 percent on average.
Studies have shown that the higher the HbA1c, the greater the chance for developing long-term problems related to diabetes. This includes problems such as heart disease, diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. By getting blood sugar levels under control with rosiglitazone and glimepiride, it may be possible to decrease the chances for developing these diabetes complications.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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