Endocrine System Home > Drug Interactions With Repaglinide and Metformin
Triamterene or Triamterene/HCTZ
Theoretically, triamterene may affect the ability of the kidneys to filter metformin (one of the components of repaglinide and metformin) from the blood, possibly leading to high levels of metformin. Your healthcare provider may need to monitor you more closely if you take these medications together.
Studies suggest that trimethoprim may increase the level of repaglinide and metformin in the blood, perhaps increasing the risk of side effects. Your healthcare provider may need to decrease your dose of repaglinide and metformin if you are taking these two medications together.