Endocrine System Home > Pioglitazone and Metformin
Pioglitazone and metformin is prescribed for the treatment of type 2 diabetes in adults. The combination medication reduces and controls blood sugar levels by improving insulin sensitivity and decreasing the amount of sugar absorbed into the body. Potential side effects include urinary tract infections, nausea, or weight gain. Pioglitazone and metformin comes in a tablet form and is typically taken once or twice a day.
- Pioglitazone is part of a class of diabetes medications called thiazolidinediones (or sometimes called "glitazones"). It helps to improve insulin sensitivity. This means that pioglitazone helps your body respond to natural insulin better, which helps to lower blood sugar.
- Metformin works in several ways. It decreases the amount of sugar (glucose) made by the liver. Metformin can also decrease the amount of sugar absorbed into the body from the diet and can make insulin receptors more sensitive, helping the body respond to its own insulin better. All of these effects cause a decrease in blood sugar levels.