Endocrine System Home > Novolin N Drug Interactions

When certain medications are taken together with Novolin N, drug interactions could occur that may lead to low blood sugar. This effect can become life-threatening quite quickly, so it is important to check with your healthcare provider any time you start, stop, or change the dose of any medication. Some of the medications that may cause Novolin N interactions include salicylates, ACE inhibitors, and fibrates.

An Overview of Novolin N Interactions

There are numerous different Novolin® N (NPH insulin) drug interactions, too many to list entirely in this article. Interactions that may increase blood sugar levels are not discussed in this article, since high blood sugar is unhealthy but usually not dangerous right away (although extremely high blood sugar can become quite serious if left untreated). This article focuses on Novolin N drug interactions that can result in dangerously low blood sugar levels (hypoglycemia), which can become life-threatening quite quickly. Some of the medicines that may cause dangerously low blood sugar levels when combined with Novolin N include, but are not limited to:
  • ACE inhibitors (angiotensin-converting enzyme inhibitors), such as:







  • Monoamine oxidase inhibitors (MAOIs), such as:




    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)


  • Sulfonamides ("sulfa drugs"), such as:


    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)


Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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