Endocrine System Home > Korlym

Korlym is a medication prescribed to help reduce blood sugar levels in people who have Cushing's syndrome in addition to either type 2 diabetes or glucose intolerance due to high cortisol levels. It comes as a tablet and is taken once daily with meals. This drug works by binding to cortisol receptors and reducing the effects of cortisol. Possible side effects include nausea, fatigue, and headaches.

What Is Korlym?

Korlym™ (mifepristone) is a prescription medication approved to treat certain people with Cushing's syndrome who have type 2 diabetes or glucose intolerance due to high cortisol levels. It is for use in people who have failed surgery or cannot have surgery.
 
(Click Korlym Uses for more information on this topic, including possible off-label uses.)
 

Who Makes This Medication?

Korlym is made by Corcept Therapeutics Incorporated.
 

How Does Korlym Work?

Korlym is a cortisol receptor blocker. It works by preventing cortisol from binding to its receptor, and thus reducing the effects of cortisol, such as high blood sugar. However, Korlym does not decrease the production of cortisol by the body.
 

Clinical Effects

Korlym was shown to reduce blood sugar levels in a clinical study of people who had endogenous Cushing's syndrome with diabetes and high cortisol levels. In this study, 60 percent of people given the drug had at least a 25 percent decrease in their blood sugar levels.
 

When and How to Take It

Some general considerations to keep in mind during treatment with Korlym include the following:
 
  • This medication comes in tablet form. It is usually taken by mouth once a day.
  • You should take Korlym with food.
  • Try to take your dose at the same time each day to keep an even level of the drug in your bloodstream.
  • Korlym should be swallowed whole. Do not crush, cut, or chew the tablets.
  • For the medication to work properly, it must be taken as prescribed.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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