Endocrine System Home > Insulin Lispro

Insulin lispro is a medication licensed to treat type 1 and type 2 diabetes. This rapid-acting insulin, which is available by prescription only, is injected within 15 minutes before or after a meal to help control blood sugar levels, which often spike after eating. This product is usually used with a long-acting insulin to provide a steady level of insulin throughout the day.

What Is Insulin Lispro?

Insulin lispro (Humalog®) is a prescription form of insulin used to treat type 1 and type 2 diabetes. It is a rapid-acting insulin, used to help control the spike in blood sugar that occurs after meals. It is typically used in combination with a long-acting insulin. Insulin lispro can also be used in an insulin pump.
 
This article refers to plain insulin lispro. This product is also available in combination with an intermediate-acting insulin (Humalog Mix75/25® and Humalog Mix50/50®).
 
(Click What Is Insulin Lispro Used For? for more information on this topic, including possible off-label uses.)
 

Are There Side Effects?

As with any medicine, side effects are possible with insulin lispro. However, not everyone who uses the medication will experience problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can be treated easily by you or your healthcare provider. Serious reactions are less common.
 
Possible side effects seen with insulin lispro (as well as all other forms of insulin) include but are not limited to:
 
  • Low blood sugar levels (hypoglycemia)
  • A skin reaction at the injection site
  • Thickening or pitting of the skin at the injection site.
     
(Click Side Effects of Insulin Lispro to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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