Endocrine System Home > Insulin Lispro Protamine/Insulin Lispro

Insulin lispro protamine/insulin lispro is a prescription medication used for controlling blood sugar in people with diabetes. It contains a rapid-acting insulin and an intermediate-acting insulin, starts working quickly, and continues to work for several hours. Insulin lispro protamine/insulin lispro comes in injectable form and is injected just under the skin before meals twice a day, within 15 minutes before you start eating.

What Is Insulin Lispro Protamine/Insulin Lispro?

Insulin lispro protamine/insulin lispro (Humalog® Mix50/50, Humalog® Mix75/25) is a prescription insulin medication used for the treatment of diabetes. It contains a mixture of two different types of insulin and is taken just before meals (often just twice a day). Ideally, using this type of insulin decreases the number of injections per day (since it combines two types of insulin in one injection).
(Click What Is Insulin Lispro Protamine/Insulin Lispro Used For? for more information, including possible off-label uses.)

Potential Side Effects

As with any medicine, side effects are possible with insulin lispro protamine/insulin lispro. As with all insulins, insulin lispro protamine/insulin lispro side effects can be quite dangerous, especially if the dose is too high.
Possible side effects of insulin lispro protamine/insulin lispro (as well as all other forms of insulin) include, but are not limited to:
  • Low blood sugar levels (hypoglycemia)
  • A skin reaction at the injection site
  • Thickening or pitting of the skin at the injection site
  • Allergic reactions.
(Click Side Effects of Insulin Lispro Protamine/Insulin Lispro to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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