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Drug Interactions With Liraglutide

When taking liraglutide by itself, the risk for low blood sugar is low. However, taking liraglutide with insulin or oral drugs that increase insulin production (such as Starlix or Tolinase) can increase your risk of dangerously low blood sugar. Interactions can also occur when liraglutide is combined with drugs that are sensitive to small changes, such as warfarin; you may require extra monitoring.

An Introduction to Liraglutide Interactions

Liraglutide (Victoza®) could potentially interact with other drugs, at least in a theoretical manner. For example, it may decrease the absorption of other medications, and some medications may increase the risk of low blood sugar in people taking liraglutide.

Liraglutide and Drug Absorption

Liraglutide is a prescription diabetes medication that works, in part, by slowing the movement of food through the stomach. While this action is helpful for controlling blood sugar, it could decrease the absorption of other medications, since most medications are much better absorbed from the small intestine, not the stomach.
With most drugs, this is likely not a problem. However, this interaction could be a problem for any medication that is quite sensitive to small changes.
For instance, liraglutide could decrease the absorption of warfarin (Coumadin®, Jantoven®), an anticoagulant "blood thinner" medication. However, such interactions are still largely theoretical, and studies have not shown liraglutide to decrease the absorption of other drugs to any clinically significant degree.
As a result, it is a good idea to have a discussion with your healthcare provider or pharmacist about possible drug interactions before starting liraglutide, or before starting any other medications, if you are already taking liraglutide. He or she can review your other medicines to see if any of them may be particularly sensitive to any small changes. If you happen to be taking such medications, you may need to be monitored a little more frequently than usual.
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Liraglutide Drug Information

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