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Linagliptin Side Effects

Common Side Effects

Linagliptin has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking linagliptin were documented and then compared to the side effects that occurred in a similar group of people taking a placebo (a "sugar pill" that does not contain any active ingredients). As a result, it is possible to see what side effects occurred, how often they appeared, and how they compared to the group taking the placebo.
 
In some of the studies, linagliptin (or the placebo) was used alone; in other studies, linagliptin (or the placebo) was combined with other diabetes medications.
 
In these studies, the most commonly reported linagliptin side effects included:
 
  • Nasopharyngitis (a term for common cold-like symptoms, such as a runny or stuffy nose or a sore throat) -- in up to 4.3 percent of people
  • High cholesterol -- up to 2.7 percent
  • Coughing -- up to 2.4 percent
  • High triglycerides -- up to 2.4 percent
  • Weight gain -- up to 2.3 percent.
 
These statistics may be slightly misleading. When looking at the "big picture" of the various studies with this medication, none of these side effects seem to be strongly linked with linagliptin. For instance, weight gain was seen in only one study in which linagliptin was combined with pioglitazone (Actos®); it was not seen in any of the other studies in which linagliptin was used alone or combined with any other diabetes medications.
 

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
 
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking linagliptin or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
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