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Linagliptin

What If I Forget a Dose of Linagliptin?

If you forget to take your dose, take the missed dose as soon as you remember. However, if it is almost time for your next dose, simply skip the missed dose and continue with your regular schedule. Do not take a double dose.
 

How Does It Work?

Linagliptin is part of a class of diabetes medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones. As a DPP-4 inhibitor, linagliptin slows down the breakdown of incretin hormones, increasing the level of these hormones in the body. It is this increase in incretin hormones that is responsible for the beneficial actions of linagliptin, such as increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
 
Because incretin hormones are more active in response to higher blood sugar levels, the risk of dangerously low blood sugar levels (hypoglycemia) is low with linagliptin.
 

Clinical Effects

There have been several studies done to determine the effects of linagliptin for type 2 diabetes.
 
Linagliptin and Hemoglobin A1c
Hemoglobin A1c (HbA1c) is a test used to measure long-term blood sugar control. For people without diabetes, HbA1c results are usually less than 6 percent, while people with diabetes usually have higher results. In one study, people taking linagliptin lowered their HbA1c by 0.4 percent on average, while people not taking this drug increased their HbA1c by 0.3 percent.
 
Studies have shown that the higher the HbA1c, the greater the chance for developing long-term problems related to diabetes. This includes problems such as heart disease, diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. By controlling blood sugar levels with linagliptin, it may be possible to decrease the chances for developing these diabetes complications. However, studies have not yet shown that linagliptin, or any other diabetes medication, prevents these complications.
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Linagliptin Drug Information

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