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Linagliptin/Metformin

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking this medication if you have:
 
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • An alcohol problem
  • An upcoming radiology procedure that will require the use of contrast dye
  • Pernicious anemia
  • Type 1 diabetes
  • Diabetic ketoacidosis
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
 
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings with Linagliptin/Metformin to learn more, including information on who should not take the drug.)
 

How Does It Work?

Linagliptin/metformin contains two different diabetes medications. Linagliptin belongs to a class of diabetes medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones.
 
As a DPP-4 inhibitor, linagliptin slows the breakdown of incretin hormones, increasing the level of these hormones in the body. It is this increase in incretin hormones that is responsible for the beneficial actions of linagliptin, such as increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
 
Because incretin hormones are more active in response to higher blood sugar levels, the risk of dangerously low blood sugar (hypoglycemia) is low with linagliptin.
 
Linagliptin/metformin also contains metformin, a biguanide medication. Metformin works in several ways, such as:
 
  • Decreasing the amount of sugar (glucose) the liver produces
  • Reducing the amount of sugar the body absorbs from the diet
  • Increasing the sensitivity of insulin receptors to improve how the body responds to its own insulin.
 
All of these effects help to control blood sugar levels.
 
Steps to Prevent or Delay Diabetic Nerve Damage

Linagliptin/Metformin Drug Information

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