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Drug Interactions With Linagliptin/Metformin

P-glycoprotein Inducers
P-glycoprotein is a normal protein found throughout the body. One of its roles is to "pump" harmful or toxic substances out of the tissues so that they can be excreted through the urine or feces.
 
P-glycoprotein helps to remove linagliptin/metformin from the body. However, medications known as P-glycoprotein inducers increase the activity of these proteins. Thus, combining linagliptin/metformin with one of these drugs may cause the body to remove linagliptin/metformin too quickly, potentially making it less effective.
 
Phenothiazines
Taking linagliptin/metformin with phenothiazines can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping a phenothiazine.
 
Phenytoin
Taking linagliptin/metformin with phenytoin can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping a phenytoin.
 
Sulfonylureas
Linagliptin/metformin may increase the risk of low blood sugar due to sulfonylurea diabetes medications. Your healthcare provider may need to lower the dosage of your sulfonylurea.
 
Thyroid Medications
Taking linagliptin/metformin with thyroid medications can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping a thyroid medication.
 
Diabetes Tips for Seniors

Linagliptin/Metformin Drug Information

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