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Drug Interactions With Linagliptin/Metformin

Digoxin
Taking digoxin and linagliptin/metformin together may affect the levels of these medications in your blood. Your healthcare provider should monitor the level of digoxin in your blood, especially when starting or stopping linagliptin/metformin.
 
Diuretics
Taking linagliptin/metformin with a diuretic can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping a diuretic.
 
Estrogens
Taking linagliptin/metformin with estrogens can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping an estrogen.
 
Isoniazid
Taking linagliptin/metformin with isoniazid can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping isoniazid.
 
Niacin
Taking linagliptin/metformin with niacin can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping niacin.
 
Oral Contraceptives
Taking linagliptin/metformin with oral contraceptives (birth control pills) can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping an oral contraceptive.
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Linagliptin/Metformin Drug Information

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