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Drug Interactions With Linagliptin/Metformin

More Detail on Drug Interactions With Linagliptin/Metformin

The following sections explain in detail the potentially negative interactions that can occur when linagliptin/metformin is combined with any of the drugs listed above.
 
Calcium Channel Blockers
Taking linagliptin/metformin with calcium channel blockers can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dosage, especially when starting or stopping a calcium channel blocker.
 
Certain Decongestants
Taking linagliptin/metformin with certain decongestants can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). Decongestants are in many cough and cold products, so make sure to talk to your healthcare provider before taking any cough or cold products.
 
Cimetidine
Taking linagliptin/metformin with cimetidine can increase the level of linagliptin/metformin in your blood, increasing your risk for side effects. Your healthcare provider may need to adjust your dose of these medications, or may suggest an alternative to cimetidine.
 
Corticosteroids
Taking linagliptin/metformin with corticosteroids can make linagliptin/metformin less effective, increasing your risk for high blood sugar levels (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your linagliptin/metformin dose, especially when starting or stopping a corticosteroid.
 
CYP 3A4 Inducers
The liver breaks down linagliptin/metformin using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining linagliptin/metformin with one of these drugs may decrease the level of linagliptin/metformin in your body, potentially making it less effective.
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Linagliptin/Metformin Drug Information

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