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Drug Interactions With Levothyroxine

Digoxin
Levothyroxine can make digoxin less effective, which can be dangerous. Check with your healthcare provider, as he or she may need to increase your digoxin dose.
 
Estrogens
Estrogens can lower the level of levothyroxine in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your levothyroxine dose if you start or stop taking an estrogen medication.
 
Iron
Iron can bind to levothyroxine in the digestive tract, decreasing the absorption of levothyroxine into the body. Make sure to separate levothyroxine and iron supplements by at least four hours.
 
Orlistat
Orlistat may decrease the absorption of levothyroxine into the body. Your healthcare provider should check your thyroid function if you start (or stop) taking orlistat. Your levothyroxine dosage may need to be adjusted.
 
Raloxifene
There have been reports that raloxifene may decrease the absorption of levothyroxine into the body, although it is not clear if this is a significant drug interaction.
 
Rifampin
Taking levothyroxine with rifampin may change the amount of levothyroxine your body needs. As a result, your healthcare provider may need to adjust your levothyroxine dosage.
 
Some Seizure Medications
Taking levothyroxine with some seizure medications may change the amount of levothyroxine your body needs. As a result, your healthcare provider may need to adjust your levothyroxine dosage.
 
Sucralfate
Sucralfate can bind to levothyroxine in the digestive tract, decreasing the absorption of levothyroxine into the body. Make sure to separate levothyroxine and sucralfate by at least four hours.
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Levothyroxine Sodium Tablets

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