Levothyroxine Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
levothyroxine is combined with any of the drugs listed above.
Antacids or Gas-Relieving Medications
Antacids or medications for gas relief can bind to levothyroxine in the digestive tract, decreasing the absorption of levothyroxine into the body. Make sure to separate levothyroxine and antacids or gas-relieving medications by at least four hours.
Antidepressant Medications
Combining levothyroxine with some
antidepressants may change the amount of levothyroxine your body needs, and your healthcare provider may need to adjust your
levothyroxine dosage. Also, taking certain antidepressants with levothyroxine may increase the risk of heart problems, such as an irregular heart rhythm (arrhythmia). Be sure to check with your healthcare provider before taking these medications together.
Calcium Supplements
Calcium can bind to levothyroxine in the digestive tract, decreasing the absorption of levothyroxine into the body. Make sure to separate levothyroxine and calcium by at least four hours.
Cholestyramine
Cholestyramine can bind to levothyroxine in the digestive tract, decreasing the absorption of levothyroxine into the body. Make sure to separate levothyroxine and cholestyramine by at least four hours.
Colestipol
Colestipol can bind to levothyroxine in the digestive tract, decreasing the absorption of levothyroxine into the body. Make sure to separate levothyroxine and colestipol by at least four hours.
Diabetes Medications
When you first start levothyroxine (or increase your dose), your healthcare provider may need to increase the dose of your
diabetes medications. If you are taking diabetes medications, check with your healthcare provider before taking levothyroxine.
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