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Korlym Warnings and Precautions

Specific Precautions and Warnings With Korlym

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • Korlym is a pregnancy Category X medication because it can harm an unborn child (see Korlym and Pregnancy). Women who are pregnant or may become pregnant should not take this medicine.
    • Muscle weakness
    • Nausea
    • Fatigue
    • Low blood pressure (hypotension), which could cause dizziness
    • Low blood sugar (hypoglycemia), which could cause sweating, nausea, and anxiety.
  • Because Korlym can decrease the level of potassium in your blood (known medically as hypokalemia), your healthcare provider will check your potassium levels using a simple blood test before you start the medication and throughout treatment. He or she may recommend treatment with potassium supplements if you develop hypokalemia. Let your healthcare provider know if you have any signs of low potassium, such as muscle weakness or cramps or an abnormal or irregular heartbeat.
  • Women who take this medicine may develop an overgrowth or thickening of the lining of the uterus and vaginal bleeding. Let your healthcare provider know if you have any unusual or unexplained vaginal bleeding during treatment.
  • Korlym can cause a potentially life-threatening problem with the heart rhythm, known as QT prolongation, especially at higher doses. Therefore, your healthcare provider will give you the lowest dose that controls your symptoms. Taking Korlym with other QT-prolonging medicines may increase the risk for this problem (see Korlym Drug Interactions).
  • Medications known as corticosteroids may not work as well in people taking Korlym. As a result, people who take corticosteroids for other medical conditions may have worsening symptoms of these other conditions when Korlym and corticosteroids are taken together. People who need corticosteroids for life-threatening conditions should not take Korlym.
  • People who take this medication are at risk for a fungal infection of the lungs known as Pneumocystis jiroveci pneumonia. Contact your healthcare provider if you develop signs of a lung infection, such as a cough, shortness of breath, and fever.
  • Korlym passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Korlym and Breastfeeding).
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