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Korlym Drug Interactions

CYP 3A4 Inhibitor Medications
The liver breaks down Korlym using enzymes known as CYP 3A4 enzymes, and medications called CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Korlym with one of these drugs may increase the level of Korlym in your body, potentially increasing your risk for side effects. Talk to your healthcare provider before taking Korlym with a CYP 3A4 inhibitor. He or she may give you a lower Korlym dosage.
Dihydroergotamine and Ergotamine
Korlym can increase the level of dihydroergotamine and ergotamine in your blood, potentially increasing your risk for serious side effects. In general, Korlym should not be used in combination with these drugs.
Korlym can increase fentanyl blood levels, which could increase your risk for potentially serious side effects, including severe sedation. Talk to your healthcare provider before taking these medicines together.
Korlym may increase the amount of efavirenz in your body, possibly increasing your risk for serious efavirenz side effects. If you take these medicines together, your healthcare provider may choose to monitor you more closely.
Hormonal Contraception
Korlym may decrease the effectiveness of hormonal contraception. If you are a woman of childbearing potential, you should talk to your healthcare provider about appropriate nonhormonal contraception options during Korlym treatment. It is important to avoid pregnancy while you are taking this medicine.
QT-Prolonging Medications
Korlym can cause a change in the heart rhythm known as QT prolongation. Taking it with other medicines that cause QT prolongation (a certain change in the heart rhythm) may increase the risk for this life-threatening arrhythmia.
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Korlym Drug Information

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