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Korlym Drug Interactions

Korlym Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Korlym is combined with any of the drugs listed above.
 
Bupropion
Korlym can increase the level of bupropion in your body, which could increase your risk for bupropion side effects. Talk to your healthcare provider if you will be taking these medicines together. If you experience side effects, your healthcare provider may recommend a lower bupropion dosage.
 
Certain Statin Medicines
Korlym may increase blood levels of certain statin medicines, which could increase your risk for potentially serious side effects, including muscle problems. This interaction does not occur with all statin medications. Therefore, if you need a statin, your healthcare provider will choose one that does not interact with Korlym.
 
Corticosteroids
Korlym may decrease the effectiveness of corticosteroid medicines. Therefore, people who take corticosteroids for serious or life-threatening conditions, such as to prevent a transplant rejection, should not use Korlym. Talk to your healthcare provider about this potential interaction if you are on long-term corticosteroid treatment.
 
Cyclosporine
Korlym can increase the level of cyclosporine in your body, increasing your risk for potentially serious side effects. In general, these medicines should not be used together.
 
CYP 3A4 Inducer Medications
The liver breaks down Korlym using enzymes known as CYP 3A4 enzymes, and medications called CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining Korlym with one of these drugs may decrease the level of Korlym in your body, potentially making it less effective. Talk to your healthcare provider before taking these medications together.
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