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Korlym Dosage

When controlling high blood sugar in people with Cushing's syndrome, the recommended starting dosage of Korlym is usually 300 mg once daily. Each dose should be taken at approximately the same time every day along with food. The specific amount you receive will depend on how you respond to the medicine, other drugs you are taking, and other factors.

An Introduction to Dosing With Korlym

The dose of Korlym™ (mifepristone) your healthcare provider recommends may vary, based on a number of factors, such as:
  • How you respond to the medicine
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Korlym Dosage?

The usual initial Korlym dosage to control high blood sugar (hyperglycemia) in people with Cushing's syndrome is 300 mg once a day. Your healthcare provider may increase your amount by 300 mg every two to four weeks if you are tolerating the medicine and higher doses are needed to adequately control your symptoms.
The highest recommended dose of Korlym is usually 1200 mg a day or 20 mg per kg body weight (about 9.1 mg per lb). People with kidney disease or mild-to-moderate liver disease should not take more than 600 mg a day.
If you experience intolerable or potentially dangerous Korlym side effects, your healthcare provider may reduce your dose, or recommend you stop taking the medication. If you stop the medicine and later start taking it again, you will be restarted at the initial recommended dose of 300 mg a day, which can be gradually increased.

General Information on Taking Korlym

Some considerations to keep in mind during treatment with Korlym include the following:
  • This medication comes in tablet form. It is usually taken by mouth once a day.
  • You should take Korlym with food.
  • Try to take your dose at the same time each day to keep an even level of the drug in your bloodstream.
  • Korlym should be swallowed whole. Do not crush, cut, or chew the tablets.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your dosage or Korlym dosing in general, please talk with your healthcare provider or pharmacist.
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