Janumet uses are primarily focused on the treatment of type 2 diabetes. Since the medication has not been adequately studied in children, it is only approved for use in adults. While a number of prescription drugs can be used "off-label" for treating conditions that are not FDA-approved, there are no universally accepted off-label Janumet uses at this time.
Janumet® (sitagliptin and metformin) is a prescription medication that is used to treat type 2 diabetes (also known as non-insulin-dependent diabetes or adult-onset diabetes). It is a combination medication, containing sitagliptin (Januvia®) and metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). The medication is typically used when blood sugar cannot be adequately controlled by sitagliptin or metformin alone.
Janumet Uses for Type 2 DiabetesType 2 diabetes is the most common type of diabetes (see Diabetes Types). It is also sometimes called adult-onset diabetes or non-insulin-dependent diabetes. Type 2 diabetes is a condition in which cells do not respond to insulin as well as they normally should. As a result, the cells do not take sugar out of the blood very well. This is why people with type 2 diabetes have high blood sugar.
Over time, high blood sugar can lead to a number of problems, including:
The cause of type 2 diabetes is not fully understood, although it is known that obesity and genetics play important roles.
Janumet contains two different diabetes medications -- sitagliptin and metformin. Sitagliptin is part of a class of diabetes medication called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones. As a DPP-4 inhibitor, Janumet slows down the breakdown of incretin hormones, increasing the level of these hormones in the body. This increase is responsible for the beneficial actions of Janumet, including increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
Metformin is part of a class of diabetes medication known as biguanide medication. It works in several ways. It decreases the amount of sugar (glucose) made by the liver, decreases the amount of sugar absorbed into the body from the diet, and makes insulin receptors more sensitive, helping the body respond to its own insulin better. All of these effects cause a decrease in blood sugar levels and a better control of blood sugar.