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Janumet Side Effects
Nausea, vomiting, diarrhea, and stomach pain are the most commonly reported Janumet side effects. These side effects are typically minor, but some problems may be more serious and should be reported immediately to your healthcare provider. Seek prompt medical attention if you develop serious side effects of Janumet, such as signs of an allergic reaction or symptoms of high or low blood sugar.
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As with any medicine, side effects are possible with Janumet® (sitagliptin and metformin); however, not everyone who takes the medication will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Janumet. Your healthcare provider can discuss a more complete list of Janumet side effects with you.)
Janumet has been studied thoroughly in clinical trials, in which a group of people taking the drug have side effects documented and compared to another group not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, the most common side effects of Janumet included:
- Diarrhea -- in up to 2.4 percent of people
- Abdominal pain (stomach pain) -- up to 2.2 percent
- Nausea -- up to 1.3 percent
- Vomiting -- up to 1.1 percent
Some side effects with Janumet, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
- Signs of pancreatitis (inflammation or infection of the pancreas), such as:
- Nausea
- Vomiting
- Loss of appetite
- Severe, persistent abdominal pain that sometimes radiates to the back
- Symptoms of low blood sugar (which can occur if Janumet is taken with other diabetes drugs), such as:
- Sweating
- Shakiness
- Extreme hunger
- Dizziness
- Cold sweats
- Blurry vision
- Changes in behavior, such as irritability
- Loss of coordination
- Difficulty speaking
- Confusion
- Seizures
- Signs of an allergic reaction, such as:
- Unexplained skin rash
- Itching
- Hives
- Wheezing or difficulty breathing
- Unexplained swelling.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD