Janumet Drug Interactions

A number of medications should not be taken with Janumet. Drug interactions may occur if the combination diabetes medication is taken with calcium channel blockers, corticosteroids, diuretics, or estrogens. These interactions can decrease the effectiveness of Janumet, which can increase your risk of developing high blood sugar. If Janumet drug interactions are a concern, your healthcare provider may adjust your dosages.

 

An Overview of Janumet Drug Interactions

Janumet® (sitagliptin and metformin) may potentially interact with a number of other medicines. Some of these medicines that may lead to Janumet drug interactions include:
 
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Calcium channel blockers, such as:
o Betamethasone (Celestone®)
o Cortisone
o Dexamethasone (Decadron®)
o Fludrocortisone (Florinef®)
o Hydrocortisone (Cortef®)
o Methylprednisolone (Depo-Medrol®, Medrol®)
o Prednisolone (Ovapred®, Pediapred®)
o Triamcinolone (Kenalog®, Aristospan®)
  • Digoxin (Digitek®, Lanoxin®)
     
  • Diuretics, such as:
o Acetazolamide (Diamox®)
o Chlorthalodone
o Promethazine (Phenergan®)
(Janumet Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;