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Janumet and Pregnancy

In clinical studies on Janumet and pregnancy, metformin and sitagliptin (the active components) did not cause problems when given to pregnant animals. Since the combination drug has not been adequately studied in pregnant humans, however, talk to your healthcare provider about the benefits and possible risks. If you are taking Janumet and pregnancy occurs, your healthcare provider will consider your particular situation before making a recommendation.

Is It Safe to Take Janumet During Pregnancy?

Janumet® (sitagliptin and metformin) is generally considered safe for women to take when pregnant. This conclusion is based on animal studies that looked at the effects of the drug during pregnancy.

Janumet and Pregnancy Category B

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category B is given to medicines that have not been studied in pregnant humans but that do not appear to cause harm to the fetus in animal studies.
In these studies, sitagliptin and metformin (the active ingredients of Janumet) did not cause any problems in pregnant animals. However, the drug has not been adequately studied in pregnant women.

Janumet and Pregnancy: Recommendations

If you are taking Janumet and pregnancy occurs, or if you are thinking about becoming pregnant while taking the drug, let your healthcare provider know. He or she will consider both the benefits and risks of taking the drug during pregnancy before making a recommendation in your particular situation.
(Click Diabetes and Pregnancy for more information.)
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