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Insulin Lispro Protamine/Insulin Lispro Dosage

There is not a single, "standard" insulin lispro protamine/insulin lispro dosage that will work for all people or even for the same person in all situations. Your healthcare provider will help you decide which strength is a better choice (one contains more rapid-acting insulin than the other). Your healthcare provider may also recommend carbohydrate counting to help determine an appropriate dose.

Insulin Lispro Protamine/Insulin Lispro Dosage: An Introduction

The dose of insulin lispro protamine/insulin lispro (Humalog® Mix50/50, Humalog® Mix75/25) that your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your blood sugar levels
  • Your blood sugar goals (which can vary from person to person)
  • Your current dose of other insulins
  • The carbohydrate content of your meals
  • Other medications you are taking, including other diabetes medications
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically instructs you to do so.

Dosing Guidelines

Dosing for insulin lispro protamine/insulin lispro must be individualized for each different person. There is no "standard" dose that will work for all people or even for the same person in all situations. Insulin lispro protamine/insulin lispro is made up of two different insulins, an intermediate-acting and a rapid-acting insulin. It is typically taken within 15 minutes before the start of meals.
Your healthcare provider will help you decide if Humalog Mix50/50 or Humalog Mix75/25 would be best for you. Humalog Mix50/50 contains more of the rapid-acting insulin (and less of the intermediate-acting insulin) and is a good choice for people who need a little extra insulin to control blood sugar due to meals.
Your healthcare provider may ask you to measure your blood sugar before and after meals and may also recommend carbohydrate counting. Both of these things can help you and your healthcare provider dose your insulin lispro protamine/insulin lispro.
In some situations, you and your healthcare provider may prefer "aggressive" insulin dosing, which may help reduce the risk of long-term diabetes complications but increases the risk of dangerously low blood sugar (hypoglycemia). Some people may need more relaxed insulin dosing, especially if they live alone (making it difficult to adequately respond to low blood sugar) or if they are elderly (in which case the long-term consequences are less important).
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Insulin Lispro Protamine/Insulin Lispro

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