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Drug Interactions With Insulin Lispro Protamine/Insulin Lispro

A number of different medications can potentially cause drug interactions with insulin lispro protamine/insulin lispro, including monoamine oxidase inhibitors (MAOIs), fibrate cholesterol medicines, and sulfonamide antibiotics. When these medications are taken together with insulin lispro protamine/insulin lispro, interactions may occur that could result in low blood sugar levels (which can be extremely dangerous).

Drug Interactions With Insulin Lispro Protamine/Insulin Lispro: An Overview

Insulin medications, including insulin lispro protamine/insulin lispro (Humalog® Mix50/50, Humalog® Mix75/25), can potentially interact with numerous different medications. Because there are so many potential insulin lispro protamine/insulin lispro interactions (and because some are less dangerous than others), this article does not discuss every possible drug interaction.
Some interactions (which are not discussed in this article) may increase blood sugar levels, which is not healthy, but is usually not dangerous right away. Typically, most people will notice higher blood sugar (when testing) and will adjust their insulin dosage as recommended by their healthcare provider long before these interactions become dangerous.
However, other insulin lispro protamine/insulin lispro drug interactions can result in dangerously low blood sugar levels (known medically as hypoglycemia). Some of the medicines that may cause dangerously low blood sugar when combined with insulin lispro protamine/insulin lispro include:
  • Angiotensin-converting enzyme inhibitors ("ACE inhibitors"), such as:










    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)


  • Sulfonamide antibiotics ("sulfa drugs"), such as:


    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)
Steps to Prevent or Delay Diabetic Nerve Damage

Insulin Lispro Protamine/Insulin Lispro

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