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Humalog Mix75/25 Warnings and Precautions

To ensure the safe use of Humalog Mix75/25, warnings and precautions for the drug should be discussed with your healthcare provider before treatment begins. For example, make sure your healthcare provider is aware of any other health conditions you may have (including liver or kidney disease), as well as any other medications you are taking (including vitamins and non-prescription medications).

What Should I Tell My Healthcare Provider Before Taking Humalog Mix75/25?

Talk with your healthcare provider prior to taking Humalog® Mix75/25 (insulin lispro protamine/insulin lispro) if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Kidney disease, such as kidney failure (renal failure)
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Breastfeeding
  • Pregnant or thinking of becoming pregnant.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Humalog Mix75/25 Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Humalog Mix75/25 include the following:
  • Different types of insulin act differently, even when used at exactly the same doses. Therefore, your dosage may need to be adjusted when you are switching from any other type of insulin to Humalog Mix75/25.
  • Humalog Mix75/25 contains a rapid-acting insulin (insulin lispro) that starts working quickly. Once you inject a Humalog Mix75/25 dosage, it is essential that you start eating a meal or snack within 15 minutes in order to avoid dangerously low blood sugar levels (hypoglycemia).
  • Low blood sugar is the most common (and usually most serious) side effect of insulin medications, including Humalog Mix75/25. Make sure you and those around you know how to identify your warning signs of low blood sugar and how to respond. You must test your blood sugar levels regularly while taking Humalog Mix75/25 or any other insulin. Low blood sugar can be a life-threatening problem.
  • Humalog Mix75/25 cannot be used in pumps, injected into a muscle, or used in an IV. Also, do not mix Humalog Mix75/25 with any other type of insulin in the same syringe.
  • Liver and kidney problems may affect your dosage. Also, changes in diet or exercise, illness, or stress may affect your blood sugar levels in such a way that your dose of Humalog Mix 75/25 needs to be adjusted.
  • This diabetes medication can potentially interact with several other medications (see Humalog Mix75/25 Drug Interactions).
  • It is not known if Humalog Mix75/25 passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Humalog Mix75/25 and Breastfeeding).
  • Humalog Mix75/25 is considered a pregnancy Category B medication. This means it is probably safe for use during pregnancy (see Humalog Mix75/25 and Pregnancy).
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Humalog Mix75/25 Medication

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