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Humalog Mix75/25 Drug Interactions

When certain medications are taken with Humalog Mix75/25, interactions could occur that may affect blood sugar levels. Some of these interactions can cause potentially low blood sugar levels, which can even be fatal if left untreated. Sulfonamide antibiotics, beta blockers, and certain cholesterol medications are some of the medications that may cause negative drug interactions with Humalog Mix75/25.

Drug Interactions With Humalog Mix75/25: An Overview

Insulin medications, including Humalog® Mix75/25 (insulin lispro protamine/insulin lispro), can potentially interact with numerous different medications. Essentially, any medication that has the potential to affect blood sugar levels can interact with Humalog Mix75/25. Because there are so many potential drug interactions (and because some are less dangerous than others), this article does not discuss every possible Humalog Mix75/25 interaction.
Some interactions (which are not discussed in this article) may increase blood sugar levels, which is not healthy, but is usually not dangerous right away. Typically, most people will notice higher blood sugar levels when testing and will adjust their insulin dosage as recommended by their healthcare provider long before these interactions become dangerous.
However, other Humalog Mix75/25 drug interactions can result in dangerously low blood sugar levels (known medically as hypoglycemia). These interactions can be dangerous (even fatal), even if you check your blood sugar levels regularly. Some of the medicines that may cause dangerously low blood sugar when combined with Humalog Mix75/25 include:
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors), such as:
    • Aspirin (Ecotrin®, Bayer®, Anacin®)
    • Choline magnesium trisalicylate (Trilisate®)
    • Diflunisal (Dolobid®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
  • Sulfonamide antibiotics ("sulfa drugs"), such as:
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®)
Healthy Eating for People With Diabetes

Humalog Mix75/25 Medication

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