Side Effects of Glyburide and Metformin

As with any medication, there are potential side effects of glyburide and metformin, including abdominal pain (or stomach pain), diarrhea, and nausea. Most people, however, tolerate the medication well. When glyburide and metformin side effects do occur, in many cases they are minor and easily treated by you or your healthcare provider. If you experience more serious side effects -- such as chest pain or symptoms of low or high blood sugar -- you should report them to your healthcare provider.

 

Side Effects of Glyburide and Metformin: An Introduction

As with any medicine, there are possible side effects with glyburide and metformin (Glucovance®). However, not everyone who takes glyburide and metformin will experience side effects. In fact, most people tolerate glyburide and metformin well. When glyburide and metformin side effects do occur, in most cases they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
 
(The glyburide and metformin side effects discussed below are not a complete list of side effects reported with glyburide and metformin. Your healthcare provider can discuss a more complete list of glyburide and metformin side effects with you.)
 

Common Side Effects of Glyburide and Metformin

Glyburide and metformin has been studied thoroughly in clinical trials. In these studies, side effects that occur in a group of people taking the drug are documented and compared to side effects occurring in another group of people not taking the medicine. Based on these studies, the most common side effects of glyburide and metformin include:
  
  • Low blood sugar -- up to 37.7 percent of people (see Glucovance and Hypoglycemia)
  • Upper respiratory tract infections (similar to the common cold or flu) -- up to 17.3 percent of people
  • Diarrhea -- up to 17 percent of people
  • Nausea or vomiting -- up to 7.6 percent of people
  • Abdominal pain (or stomach pain) -- up to 6.9 percent of people
  • Dizziness -- up to 5.5 percent of people.

 

(Side Effects of Glyburide and Metformin Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;