Precautions and Warnings With Glyburide and Metformin

There are numerous precautions and warnings with glyburide and metformin to be aware of, including potential drug interactions, the risk of low blood sugar levels in some people taking the drug, and the safety of taking it while pregnant. Among the people who should not take glyburide and metformin are those who are allergic to any ingredient used to make the medication and those with diabetic ketoacidosis.

 

Glyburide and Metformin: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking glyburide and metformin (Glucovance®) if you have:
 
  • Congestive heart failure (CHF)
  • Adrenal insufficiency or pituitary insufficiency
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Low vitamin B12 levels (pernicious anemia)
  • A history of a heart attack or stroke
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • An upcoming surgery or procedure (including x-rays and other radiology procedures)
  • Any allergies, including allergies to sulfa drugs, food, dyes, or preservatives.
     
Also let your healthcare provider know if you:
 
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Drink alcohol.
     
You should also tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Precautions and Warnings With Glyburide and Metformin Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;