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Precautions and Warnings With Glyburide and Metformin

Who Should Not Take Glyburide and Metformin?

You should not take glyburide and metformin if you:
  • Are allergic to Glucovance, glyburide (DiaBeta®, Glynase®, or Micronase®), metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®), or any inactive component used to make glyburide and metformin. Your healthcare provider or pharmacist has a list of the inactive ingredients used to make glyburide and metformin.
  • Have kidney disease, including kidney failure (renal failure).
  • Have congestive heart failure (CHF) that is severe enough to require treatment with medications.
  • Have metabolic or diabetic ketoacidosis (a life-threatening condition that may occur with uncontrolled diabetes). This condition needs to be treated with insulin.
  • Are seriously dehydrated (have lost a lot of water from your body).
  • Are going to have an x-ray procedure with injection of dyes (contrast agents).
  • Are going to have surgery.
  • Develop a serious condition, such as a heart attack, a severe infection, or a stroke.
  • Are 80 years of age or older and you have not had your kidney function tested.
  • Are taking bosentan (Tracleer®), due to the risk of liver problems when these drugs are combined.

Precautions and Warnings With Glyburide and Metformin: Summary

There are several situations in which glyburide and metformin should not be taken, as well as a number of precautions and warnings people should be aware of with glyburide and metformin. However, it is possible that not all of the warnings or precautions for glyburide and metformin were discussed in this article. Therefore, you should talk with your healthcare provider about the precautions and warnings with glyburide and metformin that may apply to you.
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