Glyburide and Metformin Dosing

Glyburide and Metformin Dosage for People Switching From Metformin or Glyburide

If you are switching to glyburide and metformin from metformin or glyburide, the recommended starting dose is glyburide and metformin 2.5 mg/500 mg twice daily with meals or glyburide and metformin 5 mg/500 mg twice daily with meals. The starting glyburide and metformin dosage should not be higher than the dose of metformin or glyburide you were previously taking. Your healthcare provider can slowly increase your dose if necessary, up to a total of glyburide and metformin 20 mg/2000 mg per day.
 

General Glyburide and Metformin Dosage Information

Some considerations for people taking glyburide and metformin include:
 
  • In order to avoid an upset stomach, it is best to take glyburide and metformin with food.
     
  • Glyburide and metformin should be taken at the same time(s) each day to maintain an even level of the medicine in your blood.
     
  • If you do not take your glyburide and metformin as scheduled, take your next dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue as scheduled. Do not take a double dose of glyburide and metformin.
     
  • For glyburide and metformin to work properly, you have to take it as prescribed. Glyburide and metformin will not work if you take it in a way other than how your healthcare provider prescribed it.
     
  • If you are unsure about anything related to your dosage or glyburide and metformin dosing in general, please talk with your doctor, nurse, or pharmacist. Do not stop taking glyburide and metformin without first discussing it with your healthcare provider.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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