Drug Interactions With Glyburide and Metformin

There are a number of potential drug interactions with glyburide and metformin. Among the drugs that can possibly interact with glyburide and metformin are certain decongestants, some thyroid medications, and oral contraceptives. Some of these drug interactions can alter the level of glyburide and metformin in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to adjust your dosage of the medications.

 

Drug Interactions With Glyburide and Metformin: An Overview

Glyburide and metformin (Glucovance®) can potentially interact with several other medicines. Some of the medicines that can lead to glyburide and metformin interactions include:
 
  • Beta blockers, such as:

 

 

 

 

  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Cimetidine (Tagamet®)
     
  • Corticosteroids, such as:

 

    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)

 

  • Diuretics, such as:

 

 

  • Estrogens
     
  • Fluoroquinolone antiobiotics, including ciprofloxacin (Cipro®), gatifloxacin (Tequin®), levofloxacin (Levaquin®), moxifloxacin (Avelox®), norfloxacin (Noroxin®), and ofloxacin (Floxin®)
     
  • Isoniazid
     
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:

 

 

 

 

  • Phenytoin (Dilantin®)
     
  • Probenecid (Benuryl®, ColBenemid®)
     
  • Salicylates, such as aspirin, choline magnesium trisalicylate (Trilisate®), diflunisal (Dolobid®), and salsalate (Salflex®, Disalcid®, Amigesic®)
     
  • Sulfonamides ("sulfa drugs"), including sulfadiazine, sulfadoxine (Fansidar®), sulfamethoxazole (Bactrim®, Septra®), and sulfisoxazole (Gantrisin®)
     
  • Thyroid medications, such as levothyroxine (Levothroid®, Levoxyl®, Synthroid®, Unithroid®), liothryonine (Cytomel®), thyroid (Armour Thyroid®), and liotrix (Thyrolar®)
     
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Glyburide and Metformin Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;