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Drug Interactions With Glyburide and Metformin

There are a number of potential drug interactions with glyburide and metformin. Among the drugs that can possibly interact with glyburide and metformin are certain decongestants, some thyroid medications, and oral contraceptives. Some of these drug interactions can alter the level of glyburide and metformin in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to adjust your dosage of the medications.

Drug Interactions With Glyburide and Metformin: An Overview

Glyburide and metformin (Glucovance®) can potentially interact with several other medicines. Some of the medicines that can lead to glyburide and metformin interactions include:






    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)


  • Diuretics, such as:



  • Estrogens
  • Fluoroquinolone antibiotics, including:



  • Isoniazid
  • Monoamine oxidase inhibitors (MAOIs), including:



  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:





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Glyburide and Metformin Info

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