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Drug Interactions With Glyburide and Metformin

Phenothiazines
Taking glyburide and metformin with phenothiazines can make glyburide and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). If you are taking glyburide and metformin with a phenothiazine, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide and metformin dose -- especially when you are starting or stopping a phenothiazine.
 
Phenytoin (Dilantin)
Taking glyburide and metformin with phenytoin can make glyburide and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). If you are taking glyburide and metformin with phenytoin, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide and metformin dose -- especially when you are starting or stopping phenytoin.
 
Probenecid (Benuryl, ColBenemid)
Taking glyburide and metformin with probenecid can increase your risk of low blood sugar (hypoglycemia). If you are taking these drugs together, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide and metformin dose -- especially when you are starting or stopping probenecid.
 
Salicylates
Taking glyburide and metformin with salicylates can increase your risk of low blood sugar (hypoglycemia). If you are taking glyburide and metformin with a salicylate, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide and metformin dose -- especially when you are starting or stopping a salicylate.
 
Sulfonamides
Taking glyburide and metformin with sulfonamides can increase your risk of low blood sugar (hypoglycemia). If you are taking glyburide and metformin with a sulfonamide, you may need to be monitored more closely, and your healthcare provider may need to adjust your glyburide and metformin dose -- especially when you are starting or stopping a sulfonamide.
7 Signs of High Blood Sugar

Glyburide and Metformin Info

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