Drug Interactions With Glucotrol

When certain medications are combined, there is a potential for drug interactions. With Glucotrol, medications such as calcium channel blockers, oral contraceptives, and diuretics can lead to problems. Your risk of low or high blood sugar may be increased or the effectiveness of Glucotrol may be affected. If drug interactions with Glucotrol are a concern, your healthcare provider may adjust your Glucotrol dose or monitor you more closely.

 

Drug Interactions With Glucotrol: An Overview

Glucotrol® (glipizide) or Glucotrol XL® (glipizide extented release) can potentially interact with other medications when they are taken together. Some of these drug interactions with Glucotrol include:
 
  • Beta blockers, such as:
 
 
 
 
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or psuedoephedrine (Sudafed®)
     
  • Corticosteroids, such as:
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®). 
 
  • Diuretics, such as:
 
 
  • Estrogens
     
  • Isoniazid
     
  • Monoamine oxidase inhibitors (MAOIs), including:
 
 
  • Niacin (nicotinic acid, Niaspan®, Niacor®, Nicolar®)
     
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
 
 
 
 
  • Phenytoin (Dilantin®)
     
  • Probenecid (Benuryl®, ColBenemid®)
     
  • Salicylates, such as:
 
    • Aspirin
    • Choline magnesium trisalicylate (Trilisate®)
    • Salsalate (Salflex®, Disalcid®, Amigesic®).
 
  • Sulfonamides ("sulfa drugs"), including:
 
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®).
 
  • Thyroid medications, such as:
 
 
  • Warfarin (Coumadin®, Jantoven®).
     
(Drug Interactions With Glucotrol Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;