Glucophage

If you have type 2 diabetes, your healthcare provider may prescribe Glucophage to help control your blood sugar levels. The drug works by lowering the amount of sugar produced by the liver and by decreasing the amount of sugar the body absorbs. It comes in tablet form and is taken one to three times a day, and it is also available in an extended-release tablet that is taken once a day with your evening meal. There are possible side effects of Glucophage, including diarrhea, indigestion, and nausea.

What Is Glucophage?

Glucophage® (metformin) is a prescription medication that is licensed to treat type 2 diabetes (also known as noninsulin-dependent diabetes or adult-onset diabetes). It also comes in:
 
(Click What Is Glucophage Used For? for more information on what it is used for, including possible off-label uses.)
 

Who Makes Glucophage?

Generic Glucophage is made by numerous manufacturers. Glucophage and Glucophage XR are manufactured by Bristol-Myers Squibb.
 

How Does It Work?

Glucophage is part of a class of diabetes medications known as biguanide medications. The drug works in several ways. For example, it decreases the amount of sugar (glucose) made by the liver. The drug can also decrease the amount of sugar absorbed into the body (from the diet) and can make insulin receptors more sensitive, helping the body respond better to its own insulin. All of these effects cause a decrease in blood sugar levels.
 
Because it does not increase the amount of insulin produced by the body, it is less likely to cause dangerously low blood sugar (hypoglycemia), as many other diabetes medications can do (see Alternatives to Metformin).
 

Effectiveness

There have been several studies documenting the effects of Glucophage for type 2 diabetes. In these studies, it has been shown to decrease fasting blood sugar and to decrease hemoglobin A1c (HbA1c). HbA1c is a test used to measure long-term blood sugar control in people with diabetes. Normal HbA1c levels are usually less than 6 percent in people without diabetes; people with diabetes usually have higher HbA1c results.
 
Studies have shown that the higher the HbA1c, the greater the chance for developing long-term problems related to diabetes. This includes such problems as heart disease, diabetic retinopathy, diabetic neuropathy, and diabetic nephropathy. By getting blood sugar levels under control with Glucophage, it may be possible to decrease the chances for developing these diabetes complications.
 
Some studies also suggest that taking the drug may lead to weight loss (see Glucophage and Weight Loss).
 
(Click Benefits of Metformin for more detailed information on this topic.)
 

When and How to Take Glucophage

Some general considerations for when and how to take the medication include:
 
  • Glucophage comes in tablet form. It should be taken by mouth, usually one to three times daily. The long-acting form, Glucophage XR, should be taken once daily with your evening meal.
     
  • It should be taken with food to reduce stomach upset.
     
  • The long-acting form (Glucophage XR) should be swallowed whole and should not be broken or crushed.
     
  • It should be taken at the same time(s) each day to maintain an even level of the drug in your blood.
     
  • For the medication to work properly, it must be taken as prescribed. It will not work if you stop taking it.
     

Dosage Information

The dosage your healthcare provider recommends will vary depending on a number of factors, including:
 
  • How well your diabetes is controlled
  • Other medical conditions you may have
  • Other medications you may currently be taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 
(Click Glucophage Dosage for dosing information.)
 

Side Effects

As with any medicine, there are possible side effects. However, not everyone who takes the medication will experience side effects. In fact, most people tolerate the drug well. When side effects do occur, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider. Serious side effects are less common.
 
The most common side effects of Glucophage include:
 
  • Diarrhea
  • Nausea or vomiting
  • Gas
  • Weakness
  • Indigestion
  • Abdominal discomfort (or stomach discomfort)
  • Headache.
     
(Click Glucophage Side Effects to learn about the specific side effects of Glucophage, including serious side effects to look out for. You can also read about other possible side effects by going to:
 

Drug Interactions With Glucophage

Glucophage can potentially interact with a number of medicines.
 
(Click Drug Interactions With Glucophage for more information about these possible interactions.)
 

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Glucophage if you have:
 
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Low vitamin B12 levels (pernicious anemia)
  • Congestive heart failure (CHF)
  • Had a heart attack or stroke
  • An upcoming surgery or procedure (including x-rays and other radiology procedures)
  • Any allergies, including allergies to foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you:
 
Tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings For Glucophage for more information on this topic, including information on who should not take this drug.)
 

Alternatives to Glucophage

In general, type 2 diabetes treatment begins with lifestyle changes (for example, weight loss, exercise, and diet). If lifestyle changes alone are not effective at managing diabetes, medication, such as Glucophage, may be necessary.
 
The main goal of diabetes medicine is to lower blood sugar levels enough to reduce your risk of developing problems related to diabetes, such as heart, nerve, eye, or kidney problems. Because Glucophage can lower blood sugar levels, people may be able to lower their risk for developing problems related to high blood sugar.
 
For most people, Glucophage is quite effective at controlling blood sugar. It is also generally well-tolerated. However, side effects can occur, or the medicine may not work as well as needed. In these cases, you may need to combine Glucophage with another diabetes medicine, such as Avandia® (rosiglitazone) or insulin. You may also wish to consider a substitute for Glucophage.
 
(Click Alternatives to Metformin to learn more. To learn about controlling diabetes through lifestyle choices, click on any of the links below:
 

Overdose

People who take too much Glucophage may have overdose symptoms that could include:
 
  • Low blood sugar (hypoglycemia) (see Metformin and Blood Sugar)
  • Lactic acidosis (see Metformin and Lactic Acidosis)
  • Fainting
  • Shakiness
  • Fast heartbeat (tachycardia)
  • Confusion
  • Sweating
  • Muscle pain
  • Trouble breathing
  • Abdominal pain (stomach pain)
  • Feeling cold
  • Dizziness
  • Slow or irregular heartbeat.
     
If you happen to overdose, seek medical attention immediately.
 
(Click Metformin Overdose for more information.)
 

Storage Methods

The medication should be stored at room temperature, away from moisture or heat. Glucophage tablets should be kept in an airtight container.
 
Keep this medication and all other medications out of the reach of children.
 

What Should I Do If I Miss a Dose?

If you do not take your Glucophage as scheduled, take your next dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.
 

Strengths of Glucophage

Glucophage tablets are available in three strengths:
 
  • Glucophage 500 mg tablets
  • Glucophage 850 mg tablets
  • Glucophage 1000 mg tablets.
     
Long-acting Glucophage XR is available in two strengths:
 
  • Glucophage XR 500 mg tablets.
  • Glucophage XR 750 mg tablets.
     
Long-acting Glucophage 1000 mg tablets are also available and are sold under the brand names of Fortamet and Glumetza. A liquid version of Glucophage, called Riomet, is also available.
 

Generic Glucophage

Both brand-name and generic Glucophage and Glucophage XR are currently licensed for sale. However, generic versions of Fortamet, Glumetza, and Riomet are not licensed for sale at this time.
 
(Click Generic Glucophage for more information.)
Other Articles in This eMedTV Presentation