Drug Interactions With Glucophage

As with any medication, there are potential drug interactions with Glucophage. Taking Glucophage with other medications, such as certain decongestants, calcium channel blockers, and estrogens, can cause problems. Some of these interactions can cause Glucophage to become less effective, potentially increasing your risk of high blood sugar, or can increase the level of the medications in your blood, which can increase your chance of side effects.

 

An Overview of Glucophage Drug Interactions

Glucophage® (metformin) and Glucophage XR® (metformin ER) can potentially interact with many drugs. Some of the drugs that may lead to Glucophage interactions include:
 
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or pseudoephedrine (Sudafed®)
     
  • Calcium channel blockers, such as:
o Betamethasone (Celestone®)
o Cortisone
o Dexamethasone (Decadron®)
o Fludrocortisone (Florinef®)
o Hydrocortisone (Cortef®)
o Methylprednisolone (Depo-Medrol®, Medrol®)
o Prednisolone (Ovapred®, Pediapred®)
o Triamcinolone (Kenalog®, Aristospan®)
  • Diuretics, such as:
o Acetazolamide (Diamox®)
o Chlorthalodone
o Promethazine (Phenergan®)
(Drug Interactions With Glucophage Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;