Precautions and Warnings With Glipizide and Metformin

An awareness of precautions and warnings with glipizide and metformin can ensure a safe treatment process. For example, the drug may carry an increased risk of death due to heart or blood vessel problems, side effects such as lactic acidosis are possible, and the drug should not be taken when pregnant. Precautions and warnings with glipizide and metformin also extend to people who have kidney or liver problems, congestive heart failure, or have an upcoming surgery.
 

Glipizide and Metformin: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking glipizide and metformin (Metaglip®) if you have:
 
  • Congestive heart failure (CHF)
  • Adrenal insufficiency or pituitary insufficiency
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Low vitamin B12 levels (pernicious anemia)
  • A history of heart attack or stroke
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • An upcoming surgery or procedure (including x-rays and other radiology procedures)
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
     
Also let your healthcare provider know if you:
 
  • Are pregnant or thinking of becoming pregnant (see Metaglip and Pregnancy)
  • Are breastfeeding
  • Drink alcohol.
     
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 

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(Precautions and Warnings With Glipizide and Metformin Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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