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Glipizide and Metformin Side Effects

Adverse effects are possible when taking glipizide and metformin. Side effects that have been reported the most often include headaches, diarrhea, and upper respiratory infections. Most people, however, tolerate the medication without problems, or side effects are minor and easily treated. But if you experience serious glipizide and metformin side effects, such as chest pain, loss of coordination, or dizziness, contact your healthcare provider.

An Introduction to Glipizide and Metformin Side Effects

As with any medicine, side effects are possible with glipizide and metformin (Metaglip®). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate glipizide and metformin quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(The glipizide and metformin side effects discussed below are not a complete list of reported side effects. Your healthcare provider can discuss a more complete list with you.)

Common Glipizide and Metformin Side Effects

Glipizide and metformin has been studied thoroughly in clinical trials, with many people being evaluated. In these studies, the side effects occurring in a group of people taking the drug are always documented and compared to the side effects that occurred in a similar group of people not taking the medicine.
Based on these studies, the most common glipizide and metformin side effects include:
  • Diarrhea -- occurring in up to 18.4 percent of people
  • Headache -- in up to 12.6 percent
  • An upper respiratory tract infection (similar to the common cold) -- in up to 10.3 percent
  • Low blood sugar (hypoglycemia) -- in up to 9.3 percent (see Metaglip and Blood Sugar)
  • Muscle pain or joint pain -- in up to 8 percent
  • Nausea or vomiting -- in up to 8 percent
  • Abdominal pain (stomach pain) -- in up to 5.7 percent
  • Dizziness -- in up to 5.2 percent
  • High blood pressure (hypertension) -- in up to 3.5 percent
  • A urinary tract infection (UTI) -- in up to 1.1 percent.
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Glipizide and Metformin Information

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