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Glipizide and Metformin Side Effects

Serious Glipizide and Metformin Side Effects

Some glipizide and metformin side effects, while not as common, are potentially serious and should be reported to your healthcare provider. These include but are not limited to:
  • Signs of lactic acidosis, including:
    • Feeling tired or weak
    • Muscle pain
    • Trouble breathing
    • Stomach pain
    • Feeling cold
    • Dizziness or lightheadedness
    • Slow or irregular heartbeat
(Click Metformin and Lactic Acidosis for more information.)
  • Symptoms of high blood sugar, including:
    • Increased hunger
    • Increased thirst
    • Increased urination
    • Blurred vision
    • Fatigue
    • Shortness of breath
    • Nausea or vomiting
  • Symptoms of low blood sugar, including:
    • Sweating
    • Shakiness
    • Extreme hunger
    • Dizziness
    • Cold sweats
    • Blurry vision
    • Changes in behavior, such as irritability
    • Loss of coordination
    • Difficulty speaking
    • Confusion
    • Seizures


  • Signs of liver damage, such as:
    • Yellow skin or eyes (jaundice)
    • Unusually dark urine
    • Upper-right abdominal pain (stomach pain)
    • Easy bruising or bleeding 
  • Chest pain  
  • Signs of an allergic reaction, including:
    • An unexplained skin rash
    • Itching
    • Hives
    • Wheezing or trouble breathing
    • Unexplained swelling.
7 Signs of High Blood Sugar

Glipizide and Metformin Information

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