Glipizide and Metformin Dosing

When giving the drug to people who have never taken glipizide and metformin, dosing guidelines call for 2.5 mg/250 mg, taken once a day. However, your actual dose will depend on how well your diabetes is controlled, other medical conditions you may have, and other medications you are taking. If necessary, your healthcare provider may gradually increase your glipizide and metformin dosing to a maximum of 20 mg/2000 mg a day.

 

Glipizide and Metformin Dosing: An Introduction

Glipizide and metformin (Metaglip®) is a combination of two different diabetes drugs: glipizide (Glucotrol® or Glucotrol XL®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). The dose of glipizide and metformin that your healthcare provider prescribes will vary, depending on a number of factors, including:
 
  • How well your diabetes is controlled
  • Other medical conditions you may have
  • Other medications you are currently taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Glipizide and Metformin Dosing for People New to Metformin or Glipizide

If you are not currently taking either metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, or Riomet) or glipizide (Glucotrol or Glucotrol XL), the recommended starting dose is glipizide and metformin 2.5 mg/250 mg, taken once daily with a meal. If your diabetes is poorly controlled (if your fasting blood sugar level is greater than 280 mg/dL), the recommended starting dose may be as high as 2.5 mg/250 mg, taken twice daily with meals. Your healthcare provider may slowly increase your dose, if necessary, up to a total of 20 mg/2000 mg per day.
 
(Glipizide and Metformin Dosing Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;